Tris buffer (THAM). An appraisal of its physiologic effects and clinical usefulness.
| Title | Tris buffer (THAM). An appraisal of its physiologic effects and clinical usefulness. |
| Publication Type | Journal Article |
| Year of Publication | 1966 |
| Authors | Bleich HL, Schwartz WB |
| Journal | N Engl J Med |
| Volume | 274 |
| Issue | 14 |
| Pagination | 782-7 |
| Date Published | 1966 Apr 07 |
| ISSN | 0028-4793 |
| Keywords | Acidosis, Acidosis, Respiratory, Acids, Blood Preservation, Buffers, Citric Acid, Glucose, Humans, Poisoning, Tromethamine |
| Abstract | It has been the purpose of this discussion to review critically the physiologic considerations and clinical evidence regarding the use of Tris buffer in the treatment of acid-base disorders. It is concluded that there is little current evidence, theoretical, experimental, or clinical, to support the view that Tris has a significant therapeutic role. Some possible exceptions to this general conclusion are considered. |
| DOI | 10.1056/NEJM196604072741407 |
| Alternate Journal | N Engl J Med |
| PubMed ID | 17926886 |
| Grant List | H-759 / / PHS HHS / United States HE 5309 / / PHS HHS / United States |